Diphen

Generic Name: phenytoin (Oral route)

FEN-i-toin

Commonly used brand name(s)

In the U.S.

• Dilantin


• Dilantin-125


• Dilantin Infatabs


• Dilantin Kapseals


• Diphen


• Phenytek

In Canada

• Dilantin-30

Available Dosage Forms:

• Suspension


• Tablet, Chewable


• Capsule, Extended Release


• Capsule

Therapeutic Class: Anticonvulsant

Chemical Class: Hydantoin (class)

Uses For Diphen

Phenytoin is used to control seizures (convulsions) in the treatment of epilepsy. It is also used to prevent and treat seizures that occur during brain surgery. This medicine is an anticonvulsant that works in the brain tissue to stop seizures.

This medicine is available only with your doctor's prescription.

Before Using Diphen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of phenytoin in children.

Geriatric

No information is available on the relationship of age to the effects of phenytoin in geriatric patients. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving phenytoin.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Boceprevir


• Delavirdine


• Nifedipine


• Praziquantel


• Ranolazine


• Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abiraterone


• Apazone


• Beclamide


• Bortezomib


• Cabazitaxel


• Crizotinib


• Dasatinib


• Dronedarone


• Erlotinib


• Etravirine


• Everolimus


• Ezogabine


• Imatinib


• Infliximab


• Irinotecan


• Ixabepilone


• Ketorolac


• Lapatinib


• Lidocaine


• Linagliptin


• Lopinavir


• Maraviroc


• Methotrexate


• Naproxen


• Nilotinib


• Posaconazole


• Rivaroxaban


• Roflumilast


• Romidepsin


• St John's Wort


• Sunitinib


• Tacrolimus


• Temsirolimus


• Ticagrelor


• Tolvaptan


• Vandetanib


• Vemurafenib


• Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acetaminophen


• Acetazolamide


• Acyclovir


• Amiodarone


• Amitriptyline


• Amprenavir


• Aprepitant


• Atorvastatin


• Betamethasone


• Bexarotene


• Bleomycin


• Busulfan


• Capecitabine


• Carbamazepine


• Carboplatin


• Caspofungin


• Chloramphenicol


• Cimetidine


• Ciprofloxacin


• Cisplatin


• Clarithromycin


• Clobazam


• Clofazimine


• Clopidogrel


• Clozapine


• Colesevelam


• Cortisone


• Cyclosporine


• Desogestrel


• Dexamethasone


• Diazepam


• Dicumarol


• Dienogest


• Digitoxin


• Diltiazem


• Disopyramide


• Disulfiram


• Doxepin


• Doxorubicin Hydrochloride


• Drospirenone


• Estradiol Cypionate


• Estradiol Valerate


• Ethinyl Estradiol


• Ethosuximide


• Ethynodiol Diacetate


• Etonogestrel


• Felbamate


• Fentanyl


• Fluconazole


• Fludrocortisone


• Fluorouracil


• Fluoxetine


• Fluvoxamine


• Folic Acid


• Fosamprenavir


• Gefitinib


• Ginkgo


• Ibuprofen


• Imipramine


• Isoniazid


• Itraconazole


• Levodopa


• Levomethadyl


• Levonorgestrel


• Levothyroxine


• Medroxyprogesterone Acetate


• Meperidine


• Mestranol


• Methoxsalen


• Methsuximide


• Miconazole


• Midazolam


• Nafimidone


• Nelfinavir


• Nilutamide


• Nisoldipine


• Norelgestromin


• Norethindrone


• Norgestimate


• Norgestrel


• Oxcarbazepine


• Paclitaxel


• Pancuronium


• Paroxetine


• Phenprocoumon


• Piperine


• Prednisolone


• Prednisone


• Progabide


• Quetiapine


• Quinidine


• Quinine


• Remacemide


• Rifampin


• Rifapentine


• Risperidone


• Ritonavir


• Rufinamide


• Sabeluzole


• Sertraline


• Shankhapulshpi


• Simvastatin


• Sirolimus


• Sulfamethizole


• Sulfaphenazole


• Sulthiame


• Telithromycin


• Tenidap


• Theophylline


• Tiagabine


• Ticlopidine


• Ticrynafen


• Tirilazad


• Tizanidine


• Tolbutamide


• Topiramate


• Trazodone


• Triamcinolone


• Trimethoprim


• Tubocurarine


• Valproic Acid


• Vecuronium


• Verapamil


• Vigabatrin


• Viloxazine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Enteral Nutrition


• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bone problems (e.g., osteomalacia) or


• Depression, history of or


• Diabetes or


• Lymphadenopathy (lymph node problems) or


• Porphyria (an enzyme problem)—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal from the body.

Proper Use of phenytoin

This section provides information on the proper use of a number of products that contain phenytoin. It may not be specific to Diphen. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine may be used with other seizure medicines. Keep using all of your seizure medicines unless your doctor tells you to stop.

Do not change brands or dosage forms of phenytoin without first checking with your doctor. Different products may not work the same way. If you refill your medicine and it looks different, check with your pharmacist.

Swallow the tablet whole or chew it thoroughly before being swallowed together with a glass of water.

Measure the oral suspension with a marked measuring spoon, oral syringe, or medicine cup. Rinse the dosing spoon or cup with water after each use.

If you are receiving tube feeding preparations, it is best to take this medicine before or after a feeding.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For seizures:
  
  • For oral dosage form (extended-release capsules):
    
    • Adults—At first, 100 milligrams (mg) three times a day or 300 mg once a day. Your doctor may increase your dose as needed. For patients in the clinic or hospital (except with a history of liver or kidney disease), a loading dose of 1000 mg is divided into three doses (400 mg, 300 mg, 300 mg) and given every two hours. Then, normal maintenance dose may be started 24 hours after the loading dose.
    
    
    • Teenagers and children above 6 years of age—300 mg per day. Your doctor may increase your dose as needed.
    
    
    • Children 6 years of age and below—Dose is based on body weight and must be determined by your doctor. At first, 5 milligrams (mg) per kilogram (kg) of body weight given in two or three divided doses per day. The doctor may adjust the dose as needed.
    
    
  
  
  • For oral dosage form (suspension):
    
    • Adults—At first, 5 milliliters (mL) or 125 milligrams (mg) three times a day. Your doctor may increase your dose as needed.
    
    
    • Teenagers and children above 6 years of age—300 milligrams (mg) per day. Your doctor may increase your dose as needed.
    
    
    • Children 6 years of age and below—Dose is based on age and body weight and must be determined by your doctor. At first, 5 milligrams (mg) per kilogram (kg) of body weight given in two or three divided doses per day. Your doctor may adjust your dose as needed.
    
    
  
  
  • For oral dosage form (tablets):
    
    • Adults—At first, 100 milligrams (mg) three times a day. Your doctor may increase your dose as needed.
    
    
    • Teenagers and children above 6 years of age—300 milligrams (mg) per day, given in two or three divided doses per day. Your doctor may increase your dose as needed.
    
    
    • Children 6 years of age and below—Dose is based on age and body weight and must be determined by your doctor. At first, 5 milligrams (mg) per kilogram (kg) of body weight given in two or three divided doses per day. The doctor may adjust the dose as needed.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Diphen

It is very important that your doctor check your progress at regular visits while you are using this medicine to see if it is working properly and to allow for a change in the dose. Blood tests may be needed to check for any unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Your doctor may want you to join a pregnancy registry for patients taking a seizure medicine.

Lymph node problems may occur while using this medicine. Check with your doctor right away if you have swollen, painful, or tender lymph glands in your neck, armpit, or groin.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping completely.

If you develop a skin rash, hives, or any allergic reaction to this medicine, stop taking the medicine and check with your doctor as soon as possible.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor or your child's doctor right away.

In some patients (usually younger patients), tenderness, swelling, or bleeding of the gums (gingival hyperplasia) may appear soon after phenytoin treatment is started. To help prevent this, brush and floss your teeth carefully and regularly and massage your gums. Also, see your dentist every 6 months to have your teeth cleaned. If you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums, check with your doctor or dentist.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Avoid drinking alcohol while you are receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Diphen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Decreased coordination


• mental confusion


• nervousness


• slurred speech


• trouble with breathing, speaking, or swallowing


• unsteadiness, trembling, or other problems with muscle control or coordination

Rare

• Inability to move the eyes


• increased blinking or spasms of the eyelid


• shakiness and unsteady walk shakiness in the legs, arms, hands, or feet


• sticking out of the tongue


• trembling or shaking of the hands or feet


• twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs


• uncontrolled twisting movements of the neck, trunk, arms, or legs


• unusual facial expressions

Incidence not known

• Abdominal or stomach pain


• bleeding gums


• blistering, peeling, or loosening of the skin


• blisters, hives, or itching


• bloating of the abdomen or stomach


• blood in the urine or stools


• bloody, black, or tarry stools


• chest pain


• chills


• cough or hoarseness


• dark urine


• diarrhea


• difficulty with moving


• fainting spells


• fever with or without chills


• general feeling of discomfort or illness


• general feeling of tiredness or weakness


• hair loss


• headache


• high fever


• irregular heartbeat


• irritation in the mouth


• joint or muscle pain


• light-colored stools


• lower back or side pain


• muscle stiffness


• nausea or vomiting


• numbness, tingling, or pain in the hands or feet


• painful or difficult urination


• pale skin


• pinpoint red spots on the skin


• red skin lesions, often with a purple center


• red, irritated eyes


• redness and swelling of the gums


• shortness of breath or troubled breathing


• skin blisters


• skin rash


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swollen glands


• swollen, painful, or tender lymph glands in the neck, armpit, or groin


• unexplained bleeding or bruising


• unusual bleeding or bruising


• unusual tiredness


• upper right abdominal pain


• weakness


• weight loss


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Sleeplessness


• trouble with sleeping


• unable to sleep


• uncontrolled eye movements

Incidence not known

• Difficulty having a bowel movement (stool)


• enlarged lips


• increased hair growth on the forehead, back, arms, or legs


• pain of penis on erection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Diphen side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Diphen resources

• Diphen Side Effects (in more detail)
• Diphen Use in Pregnancy & Breastfeeding
• Drug Images
• Diphen Drug Interactions
• Diphen Support Group
• 46 Reviews for Diphen - Add your own review/rating

• Banophen MedFacts Consumer Leaflet (Wolters Kluwer)


• Ben-Tann Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Benadryl Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Benadryl Consumer Overview


• Benadryl Allergy Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Children's Allergy Prescribing Information (FDA)


• Diphenhydramine MedFacts Consumer Leaflet (Wolters Kluwer)


• Diphenhydramine Prescribing Information (FDA)


• Diphenhydramine Hydrochloride Monograph (AHFS DI)


• Diphenoxylate Hydrochloride Monograph (AHFS DI)


• Dytuss Elixir MedFacts Consumer Leaflet (Wolters Kluwer)


• Simply Sleep MedFacts Consumer Leaflet (Wolters Kluwer)


• Sominex MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Diphen with other medications

• Anxiety
• Arrhythmia
• Epilepsy
• Neurosurgery
• Peripheral Neuropathy
• Rheumatoid Arthritis
• Seizures
• Status Epilepticus
• Trigeminal Neuralgia

Disopyramide

Pronunciation: dye-soe-PEER-a-mide
Generic Name: Disopyramide
Brand Name: Norpace

Disopyramide sometimes produces new irregular heartbeats (arrhythmias). Therefore, it should be used in carefully selected patients. Consult your doctor or pharmacist for more information.

Disopyramide is used for:

Correcting or preventing various types of life-threatening irregular heartbeats and heart rhythm disturbances.

Disopyramide is an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm (antiarrhythmic effect).

Do NOT use Disopyramide if:

• you are allergic to any ingredient in Disopyramide


• you have second- or third-degree heart block and do not have a pacemaker, you were born with an irregular heartbeat due to QT prolongation, or your heart is in shock


• you are taking astemizole, cisapride, a class III antiarrhythmic (eg, amiodarone, sotalol), a phenothiazine (eg, thioridazine), pimozide, a quinolone (eg, grepafloxacin, sparfloxacin), or terfenadine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Disopyramide:

Some medical conditions may interact with Disopyramide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of certain heart conditions or irregular heart rhythms (eg, enlargement or inflammation of the heart, heart block, heart failure, heart attack, Wolff-Parkinson-White syndrome), diabetes, glaucoma, severe muscle weakness, high or low levels of potassium in the blood, or kidney or liver disease


• if you have difficulty urinating due to an obstruction of the bladder neck or prostate problems

Some MEDICINES MAY INTERACT with Disopyramide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Astemizole, beta-blockers (eg, propranolol), cisapride, class III antiarrhythmics (eg, amiodarone, sotalol), dofetilide, droperidol, ketolides (eg, telithromycin), macrolides (eg, erythromycin), phenothiazine (eg, thioridazine ), pimozide, quinolones (eg, sparfloxacin, grepafloxacin), terfenadine, verapamil, or ziprasidone because side effects, such as life threatening irregular heartbeats, may be increased


• Hydantoins (eg, phenytoin) because the effectiveness of Disopyramide may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Disopyramide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Disopyramide:

Use Disopyramide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Disopyramide may be taken with or without food.


• Take Disopyramide on a regular schedule around the clock, unless otherwise directed by your doctor.


• If you miss a dose of Disopyramide, take it if you remember within 4 hours. If it has been more than 4 hours since your missed dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Disopyramide.

Important safety information:

• Disopyramide may cause dizziness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Disopyramide.


• Do not become overheated in hot weather or during exercise or other activities; heatstroke may occur.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Disopyramide.


• Use Disopyramide with caution in the ELDERLY because they may be more sensitive to its effects.


• Use Disopyramide with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Disopyramide during pregnancy. Disopyramide is excreted in breast milk. Do not breast-feed while taking Disopyramide.

Possible side effects of Disopyramide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Aches or pain; bloating; blurred vision; constipation; difficulty urinating; dizziness; dryness of the eyes, mouth, nose, or throat; fatigue; frequent and urgent urination; gas; general body discomfort; headache; muscle weakness; nausea; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or slow heartbeat; fever; lightheadedness; heart rhythm problems; severe difficulty urinating; shortness of breath; sore throat; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Disopyramide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include change in heart rhythm; difficulty breathing; loss of consciousness.

Proper storage of Disopyramide:

Store Disopyramide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Disopyramide out of the reach of children and away from pets.

General information:

• If you have any questions about Disopyramide, please talk with your doctor, pharmacist, or other health care provider.


• Disopyramide is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Disopyramide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Disopyramide resources

• Disopyramide Side Effects (in more detail)
• Disopyramide Dosage
• Disopyramide Use in Pregnancy & Breastfeeding
• Drug Images
• Disopyramide Drug Interactions
• Disopyramide Support Group
• 4 Reviews for Disopyramide - Add your own review/rating

• Disopyramide Prescribing Information (FDA)


• disopyramide Advanced Consumer (Micromedex) - Includes Dosage Information


• disopyramide Concise Consumer Information (Cerner Multum)


• Disopyramide Phosphate Monograph (AHFS DI)


• Norpace Prescribing Information (FDA)

Compare Disopyramide with other medications

• Arrhythmia

Dipentum

Generic Name: olsalazine (ole SAL a zeen)

Brand Names: Dipentum

What is Dipentum (olsalazine)?

Olsalazine affects substances in the body that cause inflammation, tissue damage, and diarrhea.

Olsalazine is used to treat ulcerative colitis.

Olsalazine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Dipentum (olsalazine)?

You should not use this medication if you are allergic to olsalazine or to salicylates such as aspirin, Novasal, Doan's Extra Strength, Salflex, Tricosal, and others.

Before taking olsalazine, tell your doctor if you have asthma or other allergies, kidney disease, or liver disease.

Call your doctor at once if your colitis symptoms get worse, or if you have chest pain, shortness of breath, fast or pounding heartbeats, nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

What should I discuss with my healthcare provider before taking Dipentum (olsalazine)?

You should not use this medication if you are allergic to olsalazine or to salicylates such as aspirin, Novasal, Doan's Extra Strength, Salflex, Tricosal, and others.

Before taking olsalazine, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  asthma or other allergies;

  
  


• 
  

  kidney disease; or

  
  


• 
  

  liver disease.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take olsalazine.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Olsalazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Dipentum (olsalazine)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take olsalazine with a full glass of water. Store olsalazine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, and diarrhea.

What should I avoid while taking Dipentum (olsalazine)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using olsalazine.

Avoid getting a varicella (chickenpox) vaccine within 6 weeks after you stop taking olsalazine.

Dipentum (olsalazine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using olsalazine and call your doctor at once if you have any of these serious side effects:

• 
  

  worsening colitis (fever, stomach pain, cramping, or bloody diarrhea);

  
  


• 
  

  chest pain, shortness of breath, fast or pounding heartbeats; or

  
  


• 
  

  nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  mild stomach discomfort;

  
  


• 
  

  nausea, heartburn;

  
  


• 
  

  skin rash, itching;

  
  


• 
  

  headache;

  
  


• 
  

  muscle or joint pain; or

  
  


• 
  

  urinating more often than usual.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Dipentum (olsalazine)?

The following drugs can interact with olsalazine. Tell your doctor if you are using any of these:

• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  thioguanine; or

  
  


• 
  

  mercaptopurine (Purinethol).

  
  

This list is not complete and there may be other drugs that can interact with olsalazine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Dipentum resources

• Dipentum Side Effects (in more detail)
• Dipentum Use in Pregnancy & Breastfeeding
• Drug Images
• Dipentum Drug Interactions
• Dipentum Support Group
• 0 Reviews for Dipentum - Add your own review/rating

• Dipentum Prescribing Information (FDA)


• Dipentum Monograph (AHFS DI)


• Dipentum Advanced Consumer (Micromedex) - Includes Dosage Information


• Dipentum MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Dipentum with other medications

• Ankylosing Spondylitis
• Ulcerative Colitis
• Ulcerative Colitis, Active
• Ulcerative Colitis, Maintenance

Where can I get more information?

• Your pharmacist can provide more information about olsalazine.

See also: Dipentum side effects (in more detail)

Diocto Syrup

Pronunciation: DOK-yoo-sate
Generic Name: Docusate
Brand Name: Examples include Colace and Diocto

Diocto Syrup is used for:

Relieving occasional constipation.

Diocto Syrup is a stool softener. It works by helping fat and water into the stool mass to soften the stool.

Do NOT use Diocto Syrup if:

• you are allergic to any ingredient in Diocto Syrup


• you have stomach pain, nausea, vomiting, or appendicitis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diocto Syrup:

Some medical conditions may interact with Diocto Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of bowel obstruction or are on a sodium-restricted diet

Some MEDICINES MAY INTERACT with Diocto Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Mineral oil because its absorption may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diocto Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diocto Syrup:

Use Diocto Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Diocto Syrup by mouth with or without food.


• Take Diocto Syrup with a full glass of water or other liquid (8 oz/240 mL).


• Diocto Syrup may be mixed in a half glass of milk, fruit juice, or infant formula before taking it.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Drinking extra fluids while you are taking Diocto Syrup is recommended. Check with your doctor for instructions.


• A bowel movement usually occurs 1 to 3 days after the first dose.


• If you miss a dose of Diocto Syrup and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diocto Syrup.

Important safety information:

• The risk of loss of normal bowel function may be greater if you take Diocto Syrup in high doses or for a long time. Do NOT take more than the recommended dose or use for longer than 1 week without checking with your doctor.


• Do not take Diocto Syrup with other laxatives or stool softeners, unless directed by your doctor.


• Contact your doctor immediately if you develop rectal bleeding or fail to have a bowel movement after using Diocto Syrup. These may be signs of a serious condition.


• Do not use Diocto Syrup if you experience stomach pain, nausea, or vomiting, except under the direction of your doctor.


• If you notice a sudden change in bowel movements that lasts for 2 weeks or more, check with your doctor.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diocto Syrup while you are pregnant. It is not known if Diocto Syrup is found in breast milk. If you are or will be breast-feeding while you use Diocto Syrup, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Diocto Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bitter taste; cramping; diarrhea; nausea; throat irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Diocto side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; stomach cramps.

Proper storage of Diocto Syrup:

Store Diocto Syrup at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Diocto Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Diocto Syrup, please talk with your doctor, pharmacist, or other health care provider.


• Diocto Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Diocto Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Diocto resources

• Diocto Side Effects (in more detail)
• Diocto Use in Pregnancy & Breastfeeding
• Diocto Drug Interactions
• Diocto Support Group
• 0 Reviews for Diocto - Add your own review/rating

Compare Diocto with other medications

• Constipation

Diltiazem 24-Hour Extended-Release Beads Tablets

Pronunciation: dil-TYE-a-zem
Generic Name: Diltiazem
Brand Name: Cardizem LA

Diltiazem 24-Hour Extended-Release Beads Tablets are used for:

Treating high blood pressure and chronic stable angina (chest pain). It may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Diltiazem 24-Hour Extended-Release Beads Tablets are a calcium channel blocker. It works by relaxing (dilating) your blood vessels, lowering blood pressure, and decreasing heart rate, which lowers the workload of the heart. It also dilates coronary arteries, which increases blood flow to the heart.

Do NOT use Diltiazem 24-Hour Extended-Release Beads Tablets if:

• you are allergic to any ingredient in Diltiazem 24-Hour Extended-Release Beads Tablets


• you have certain heart problems (eg, sick sinus syndrome, second- or third-degree heart block) and do not have a pacemaker, you have very low blood pressure, or you have fluid buildup in the lungs during or soon after a heart attack


• you are taking erythromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diltiazem 24-Hour Extended-Release Beads Tablets:

Some medical conditions may interact with Diltiazem 24-Hour Extended-Release Beads Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart failure, a recent heart attack with lung congestion, heart block, a very slow heart rate, or other heart problems; low blood pressure; certain stomach or intestine problems (eg, narrowing); liver disease; or kidney problems


• if you are taking other medicines for high blood pressure or heart conditions

Some MEDICINES MAY INTERACT with Diltiazem 24-Hour Extended-Release Beads Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, amiodarone, dronedarone), cimetidine, clonidine, HIV protease inhibitors (eg, atazanavir, indinavir), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Diltiazem 24-Hour Extended-Release Beads Tablets's side effects, such as heart rhythm problems


• Benzodiazepines (eg, alprazolam), beta-blockers (eg, propranolol), buspirone, carbamazepine, cilostazol, cisapride, colchicine, corticosteroids (eg, hydrocortisone), cyclosporine, digoxin, everolimus, fentanyl, HMG-CoA reductase inhibitors (eg, simvastatin), hydantoins (eg, phenytoin), lurasidone, macrolide antibiotics (eg, erythromycin), macrolide immunosuppressants (eg, tacrolimus), nifedipine, quinidine, ranolazine, theophylline, or vasopressin antagonists (eg, tolvaptan) because the risk of their side effects, some potentially life-threatening, may be increased by Diltiazem 24-Hour Extended-Release Beads Tablets


• Moricizine or rifamycins (eg, rifampin) because they may decrease Diltiazem 24-Hour Extended-Release Beads Tablets's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diltiazem 24-Hour Extended-Release Beads Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diltiazem 24-Hour Extended-Release Beads Tablets:

Use Diltiazem 24-Hour Extended-Release Beads Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Diltiazem 24-Hour Extended-Release Beads Tablets by mouth with or without food.


• Swallow Diltiazem 24-Hour Extended-Release Beads Tablets whole. Do not break, crush, or chew before swallowing.


• Taking Diltiazem 24-Hour Extended-Release Beads Tablets at the same time each day will help you remember to take it.


• Continue to take Diltiazem 24-Hour Extended-Release Beads Tablets even if you feel well. Do not miss any doses.


• If you miss a dose of Diltiazem 24-Hour Extended-Release Beads Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diltiazem 24-Hour Extended-Release Beads Tablets.

Important safety information:

• Diltiazem 24-Hour Extended-Release Beads Tablets may cause dizziness, lightheadedness, or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Diltiazem 24-Hour Extended-Release Beads Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Diltiazem 24-Hour Extended-Release Beads Tablets may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Diltiazem 24-Hour Extended-Release Beads Tablets may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Diltiazem 24-Hour Extended-Release Beads Tablets. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.


• Do not suddenly stop taking Diltiazem 24-Hour Extended-Release Beads Tablets. Your condition may get worse if you suddenly stop taking it. If you need to stop Diltiazem 24-Hour Extended-Release Beads Tablets or add a new medicine, your doctor will gradually lower your dose.


• Tell your doctor or dentist that you take Diltiazem 24-Hour Extended-Release Beads Tablets before you receive any medical or dental care, emergency care, or surgery.


• Be sure to have your blood pressure checked regularly while taking Diltiazem 24-Hour Extended-Release Beads Tablets.


• Lab tests, including blood pressure, electrocardiogram (ECG), and heart rate, may be performed while you use Diltiazem 24-Hour Extended-Release Beads Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Diltiazem 24-Hour Extended-Release Beads Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially swelling of the ankles, feet, or hands; dizziness; and slow heartbeat.


• Diltiazem 24-Hour Extended-Release Beads Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Diltiazem 24-Hour Extended-Release Beads Tablets while you are pregnant. Diltiazem 24-Hour Extended-Release Beads Tablets are found in breast milk. Do not breast-feed while taking Diltiazem 24-Hour Extended-Release Beads Tablets.

Possible side effects of Diltiazem 24-Hour Extended-Release Beads Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; lightheadedness; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes; personality changes; reddened, blistered, or swollen skin; severe or persistent dizziness, lightheadedness, nausea, or vomiting; shortness of breath; sudden weight gain; swelling of the feet, ankles, or hands; symptoms of liver problems (eg, dark urine, pale stools, yellowing of the skin or eyes); tender, bleeding, or swollen gums; unusual bleeding or bruising; unusual or persistent tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Diltiazem side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; difficulty breathing, especially when lying down; dizziness; drowsiness; fainting; lightheadedness, especially when standing; loss of consciousness; nausea; nervousness; slurred speech; unusual weakness; very slow heart rate.

Proper storage of Diltiazem 24-Hour Extended-Release Beads Tablets:

Store Diltiazem 24-Hour Extended-Release Beads Tablets at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diltiazem 24-Hour Extended-Release Beads Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Diltiazem 24-Hour Extended-Release Beads Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Diltiazem 24-Hour Extended-Release Beads Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Diltiazem 24-Hour Extended-Release Beads Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Diltiazem resources

• Diltiazem Side Effects (in more detail)
• Diltiazem Use in Pregnancy & Breastfeeding
• Drug Images
• Diltiazem Drug Interactions
• Diltiazem Support Group
• 31 Reviews for Diltiazem - Add your own review/rating

Compare Diltiazem with other medications

• Angina Pectoris Prophylaxis
• Atrial Fibrillation
• Atrial Flutter
• Heart Failure
• High Blood Pressure
• Raynaud's Syndrome
• Supraventricular Tachycardia

Durabac

Pronunciation: a-seet-a-MIN-oh-fen/SAL-i-SIL-a-mide/FEN-il-tole-OX-a-meen/KAF-een
Generic Name: Acetaminophen/Salicylamide/Phenyltoloxamine/Caffeine
Brand Name: Examples include Cafgesic and Durabac

Durabac is used for:

Treating minor aches and pains (eg, headache, muscle or joint soreness, minor toothache, menstrual cramps). It is also used to treat symptoms associated with certain conditions (eg, colds, arthritis, muscle spasm, sinusitis). It may also be used for other conditions as determined by your doctor.

Durabac is an analgesic, antihistamine, and antipyretic combination. It works by blocking substances in the body that cause fever, pain, and inflammation. It also blocks histamine, which causes sneezing and itchy, watery eyes.

Do NOT use Durabac if:

• you are allergic to any ingredient in Durabac


• you have had a severe allergic reaction to aspirin or other salicylates (eg, rash, hives, itching, difficulty breathing, tightness in the chest)


• you have kidney or liver problems


• you are a child or teenager and have a viral infection (eg, chickenpox, flu, cold)


• you are taking sodium oxybate (GHB) or an anticoagulant (eg, warfarin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Durabac:

Some medical conditions may interact with Durabac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a viral infection (eg, chickenpox, flu); Kawasaki syndrome; ulcers; a blockage of your stomach, bowel, or bladder; blood or bleeding problems; blood clotting problems; heart problems; blood vessel problems; or high blood pressure.


• if you have a history of lung or breathing problems (eg, asthma, emphysema, chronic obstructive pulmonary disease [COPD]), increased pressure in the eye, glaucoma, difficulty urinating, prostate problems (eg, enlarged prostate), anxiety, trouble sleeping, or high blood sugar


• if you drink alcohol, have a history of alcohol abuse or dependence, or take a monoamine oxidase inhibitor (MAOI) (eg, phenelzine)

Some MEDICINES MAY INTERACT with Durabac. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sodium oxybate (GHB) because serious side effects such as prolonged sedation and severe drowsiness may occur


• Anticoagulants (eg, warfarin) because the risk of side effects, including the risk of bruising or bleeding, may be increased


• Aspirin, isoniazid, MAOIs (eg, phenelzine), or quinolones (eg, ciprofloxacin) because they may increase the risk of Durabac's side effects


• Theophylline because the risk of its side effects may be increased by Durabac


• Barbiturates (eg, phenobarbital) because their effectiveness may be decreased by Durabac

This may not be a complete list of all interactions that may occur. Ask your health care provider if Durabac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Durabac:

Use Durabac as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Durabac by mouth with or without food.


• If you miss a dose of Durabac and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Durabac.

Important safety information:

• Durabac may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Durabac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Durabac; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If you are taking Durabac for pain or fever and your symptoms do not improve within 10 days or if they become worse, check with your doctor.


• Durabac has acetaminophen, caffeine, an aspirin-like medicine, and an antihistamine in it. Before you start any new medicine, check the label to see if it has any of these ingredients in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Durabac contains caffeine. Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).


• Durabac may harm your liver or cause stomach bleeding. Your risk may be greater if you drink alcohol while you are using Durabac. Talk to your doctor before you take Durabac or other fever reducers if you drink more than 3 drinks with alcohol per day.


• Tell your doctor or dentist that you take Durabac before you receive any medical or dental care, emergency care, or surgery.


• Do not give Durabac to a child or teenager who has chickenpox, the flu, or another viral infection. Use of Durabac for treating the symptoms of a viral infection may cause a serious illness called Reye syndrome.


• Durabac may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Durabac.


• Use Durabac with caution in the ELDERLY; they may be more sensitive to its effects, especially liver and kidney problems.


• Durabac should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Durabac while you are pregnant. Durabac is found in breast milk. Do not breast-feed while taking Durabac.

Possible side effects of Durabac:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, nose, or throat; heartburn; nausea; thickening of mucus in the nose and throat; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black stools; blurred vision or other vision changes; dark urine; decrease in the amount of urine produced; difficulty urinating; fainting; fast or irregular heartbeat; hearing loss; involuntary trembling; loss of coordination; pale stools; ringing in the ears; seizures; severe or persistent dizziness; severe stomach pain; trouble sleeping; unusual bruising or bleeding; unusual tiredness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Durabac side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include abnormal thoughts or behavior; confusion; dark urine; excessive sweating; fast or deep breathing; fast or irregular heartbeat; general discomfort; hearing loss; high fever; involuntary trembling; ringing in the ears; seizures; severe or persistent stomach pain; trouble sleeping; vomiting; yellowing of the eyes or skin.

Proper storage of Durabac:

Store Durabac at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Durabac out of the reach of children and away from pets.

General information:

• If you have any questions about Durabac, please talk with your doctor, pharmacist, or other health care provider.


• Durabac is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Durabac. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Durabac resources

• Durabac Side Effects (in more detail)
• Durabac Use in Pregnancy & Breastfeeding
• Drug Images
• Durabac Drug Interactions
• Durabac Support Group
• 0 Reviews for Durabac - Add your own review/rating

Compare Durabac with other medications

• Pain

Duoneb

Generic Name: ipratropium and albuterol (Inhalation route)

ip-ra-TROE-pee-um BROE-mide, al-BUE-ter-ol SUL-fate

Commonly used brand name(s)

In the U.S.

• Combivent


• Combivent Respimat


• Duoneb

In Canada

• Ratio-Ipra Sal Udv

Available Dosage Forms:

• Aerosol Powder


• Solution


• Spray


• Aerosol Liquid

Therapeutic Class: Bronchodilator

Pharmacologic Class: Ipratropium

Uses For Duoneb

Ipratropium and albuterol combination is used to help control the symptoms of lung diseases, such as asthma, chronic bronchitis, and emphysema. It is also used to treat air flow blockage and prevent the worsening of chronic obstructive pulmonary disease (COPD) in patients who need another medicine.

Ipratropium and albuterol belong to the family of medicines known as bronchodilators. Bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs.

This medicine is available only with your doctor's prescription.

Before Using Duoneb

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ipratropium and albuterol combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Combivent® Respimat® spray in the elderly.

No information is available on the relationship of age to the effects of Combivent® in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Alprenolol


• Arotinolol


• Atenolol


• Atomoxetine


• Befunolol


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Brofaromine


• Bucindolol


• Bupranolol


• Carteolol


• Carvedilol


• Celiprolol


• Clorgyline


• Dilevalol


• Esmolol


• Furazolidone


• Iproniazid


• Isocarboxazid


• Labetalol


• Landiolol


• Lazabemide


• Levobetaxolol


• Levobunolol


• Linezolid


• Mepindolol


• Metipranolol


• Metoprolol


• Moclobemide


• Nadolol


• Nebivolol


• Nialamide


• Nipradilol


• Oxprenolol


• Pargyline


• Penbutolol


• Phenelzine


• Pindolol


• Procarbazine


• Propranolol


• Rasagiline


• Selegiline


• Sotalol


• Talinolol


• Tertatolol


• Timolol


• Toloxatone


• Tranylcypromine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Betel Nut

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to soya lecithin, soybean, or peanuts, history of—Combivent® brand should not be used in patients with this condition.

• Blood circulation problems or


• Heart or blood vessel disease or


• Heart rhythm problems (e.g., arrhythmia) or


• Hypertension (high blood pressure)—Use with caution. May increase risk for serious side effects.

• Diabetes or


• Difficult urination or


• Enlarged prostate or


• Hyperthyroidism (an overactive thyroid) or


• Hypokalemia (low potassium in the blood) or


• Narrow-angle glaucoma or


• Seizures or


• Urinary bladder blockage—Use with caution. May make these conditions worse.

Proper Use of ipratropium and albuterol

This section provides information on the proper use of a number of products that contain ipratropium and albuterol. It may not be specific to Duoneb. Please read with care.

This medicine usually comes with patient directions or instructions. Read them carefully before using the medicine. If you do not understand the directions or you are not sure how to use the inhaler or nebulizer, ask your doctor to show you how to use it.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine without telling your doctor. To do so may cause your lung condition to become worse.

When you use the inhalation solution, make sure you use a jet nebulizer that is connected to an air compressor with a good air flow. Use a face mask or mouthpiece to inhale the medicine.

Keep the spray away from your eyes. This medicine may cause eye pain or discomfort, irritation, blurred vision, or start seeing halos or odd colors when you look at things. If it does come into contact with your eyes, check with your doctor right away.

To use the Combivent® inhaler:

• Insert the metal canister firmly and fully into the clear end of the Combivent® Inhalation Aerosol mouthpiece. This mouthpiece should not be used with other inhaled medicines.


• Remove the cap and look at the mouthpiece to make sure it is clean.


• Shake the inhaler for at least 10 seconds and test spray it in the air 3 times before using it for the first time or if the inhaler has not been used for 24 hours.


• To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece just in front of your mouth with the canister upright.


• Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once on the top of the canister.


• Hold your breath for about 10 seconds, then breathe out slowly.


• If you are supposed to use more than one puff, wait 1 to 2 minutes before inhaling the second puff. Repeat these steps for the second puff, starting with shaking the inhaler.


• When you have finished all of your doses, rinse your mouth with water.


• Clean the inhaler mouthpiece every day with hot water. Dry it thoroughly before use.

To use the Combivent® Respimat® spray:

• Insert the cartridge into the Combivent® Respimat® inhaler.


• Before using the inhaler, prime it by spraying the medicine towards the ground (away from your face), until an aerosol cloud is visible. Repeat 3 more times. The inhaler is now ready for use.


• If the inhaler is not used for more than 3 days, prime the inhaler once to prepare it for use. If it not used for more than 21 days, prime the inhaler 3 times.


• To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible.


• Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once the release button of the inhaler.


• Hold your breath for about 10 seconds, then breathe out slowly.


• After using the inhaler, clean the mouthpiece with a damp cloth or tissue at least once a week.


• This inhaler has a dose indicator window that shows how much medicine is left. When the pointer enters the red area of the scale, it is time that you need to refill your prescription.


• Throw away the inhaler 3 months from its first use or when the inhaler is locked (after 120 puffs).

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For symptoms of chronic obstructive pulmonary disease (COPD):
  
  • For inhalation aerosol dosage form (used with an inhaler):
    
    • Adults—2 puffs four times a day and as needed. Do not use more than 12 puffs in any 24-hour period.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For inhalation solution dosage form (used with a nebulizer):
    
    • Adults—Use one 3 milliliter (mL) vial in the nebulizer four times a day. You may use 2 additional treatments per day if needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For inhalation spray dosage form (used with an inhaler):
    
    • Adults—One puff four times a day. You may take additional doses per day if needed. Do not use more than 6 puffs in any 24-hour period.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Duoneb

It is very important that your doctor check your progress closely while you are using this medicine to see if it is working properly and to help reduce any unwanted effects.

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Stop using this medicine and check with your doctor right away if you have coughing, difficulty breathing, shortness of breath, or wheezing after using this medicine.

Check with your doctor at once if difficulty with breathing continues after using a dose of this medicine or if your condition gets worse.

This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hives; hoarseness; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Tell your doctor right away if you feel chest pain, notice any changes in your blood pressure (such as feeling lightheaded or changes in vision), or notice your heart beating faster or slower .

Take all of your COPD medicines as your doctor ordered. If you use any type of corticosteroid medicine to control your breathing, keep using it as ordered by your doctor. This includes corticosteroid medicines that are taken by mouth or inhaled (such as prednisone, Azmacort®, or Flovent®). If any of your COPD medicines do not seem to be working as well as usual, call your doctor right away. Do not change your doses or stop using your medicines without asking your doctor.

This medicine may cause dizziness, blurred vision, or trouble in seeing clearly. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to see well.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements. .

Duoneb Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Body aches or pain


• chills


• cough


• cough producing mucus


• difficulty with breathing


• ear congestion


• fever


• headache


• loss of voice


• runny nose


• shortness of breath


• sneezing


• sore throat


• stuffy nose


• tightness in the chest


• unusual tiredness or weakness


• wheezing

Less common

• Bladder pain


• bloody or cloudy urine


• blurred vision


• burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• chest pain


• congestion


• diarrhea


• difficult, burning, or painful urination


• dizziness


• fainting


• fast, slow, irregular, pounding, or racing heartbeat or pulse


• frequent urge to urinate


• general feeling of discomfort or illness


• hoarseness


• increased sputum


• joint pain


• loss of appetite


• lower back or side pain


• muscle aches and pains


• nausea


• nervousness


• noisy breathing


• pain


• pain or tenderness around the eyes and cheekbones


• pounding in the ears


• shakiness in the legs, arms, hands, or feet


• shivering


• sweating


• swelling


• tender, swollen glands in the neck


• trembling or shaking of the hands or feet


• trouble with sleeping


• trouble with swallowing


• voice changes


• vomiting

Rare

• Skin rash or hives


• swelling of the face, lips, eyelids, mouth, or throat

Incidence not known

• Chest discomfort


• decrease in the frequency of urination


• decrease in urine volume


• difficulty in passing urine (dribbling)


• difficulty with swallowing


• itching skin


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• pain or discomfort in the arms, jaw, back, or neck


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• redness of the skin


• welts

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• bad, unusual, or unpleasant (after) taste


• belching


• change in taste


• diarrhea


• difficulty with moving


• dry mouth


• heartburn


• hoarseness


• indigestion


• muscle pain or stiffness


• sleeplessness


• stomach discomfort, upset, or pain


• trouble sleeping


• unable to sleep


• voice changes

Less common or rare

• Nervousness


• tremor

Incidence not known

• Bigger, dilated, or enlarged pupils (black part of the eye)


• blindness


• change in near or distance vision


• decreased vision


• difficulty in focusing eyes


• dry throat


• eye pain


• increased sensitivity of the eyes to light


• itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use


• lack or loss of strength


• noisy breathing


• redness of the white part of the eyes or inside of the eyelids


• swelling of the eye


• swelling or inflammation of the mouth


• tearing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Duoneb side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Duoneb resources

• Duoneb Side Effects (in more detail)
• Duoneb Use in Pregnancy & Breastfeeding
• Duoneb Drug Interactions
• Duoneb Support Group
• 1 Review for Duoneb - Add your own review/rating

• Combivent Prescribing Information (FDA)


• Combivent Consumer Overview


• Combivent Aerosol MedFacts Consumer Leaflet (Wolters Kluwer)


• DuoNeb Prescribing Information (FDA)


• DuoNeb Consumer Overview


• DuoNeb Solution MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Duoneb with other medications

• COPD, Maintenance